Description

This animation is targeted to second-year undergraduate students studying immunology

The purpose of this animation is to provide a visual tool that can be incorporated into the undergraduate immunology curriculum. The animation will focus on the TLR-4 pathway because it is the most widely discussed pathway in the second-year undergraduate immunology course at the University of Toronto (U of T). The animation will be embedded within lectures. They will also be made available to the students online to access at a later date.

Intended Audience

Content expert: Dr. Dana Philpott 

Supervisor: Professor Nick Woolridge

Committee member: Professor Marc Dryer

The mammalian immune system is a multi-layered system that comprises the physical barriers, the innate immune system and the adaptive immune system. The innate immune system is the first line of defence against pathogens in humans and facilitates the body’s adaptive immune response. To progress in the field of immunology, it is needless to say that students must have a clear understanding of the innate immune system. The undergraduate’s grasp of fundamental concepts is often hindered by the complexity of Toll-like receptor (TLR) signalling pathways, a vital component of the innate immune system. In particular, students have difficulty comprehending the spatial and temporal significance of key signalling events.

To address this communication problem, I created a 3D animation depicting the innate immune system through the visualization of the TLR-4 signalling pathway. This will be the first animation to incorporate accurate molecular models of the TLR-4 signalling pathway.

Medium

Autodesk Maya 2015, Adobe Illustrator CS6, Adobe After Effects CS6, Adobe Premiere Pr

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